Nutreco Feed Tech Challenge 2018

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Biome Modulators

Biome Modulators a novel feed/food additive category that removes unwanted bacteria, whilst supporting the colonies that you wish to maintain, without the use of antibiotics, so reducing the risk of AMR. 

Biome Modulators can be delivered through the water or encapsulated in feed systems in the rearing house.  They support the natural healthy state of the animal reducing the risk of disease, loss in house and improving productivity   Maintaining a healthy biome reduces the risk of disease the instances of pathogenic spikes during feeding routines.

The base technology has a US granted patent with filings across the major economic countries worldwide.      

Describe the problem your company wishes to solve and how your product or service will solve it

Antibiotic overuse contributes to increasing the reservoir of resistant bacteria, resulting in increased human mortality (10 million deaths a year globally by 2050), increased hospital stay lengths (20-30 days), and estimates of global direct- and indirect- costs up to c.£77 trillion. Currently, no new antibiotics are under development and alternatives are ineffective.  Consequently, animal production globally is under increasing pressure to reduce antibiotic use as resistance here enters the human food chain. However, limiting the availability of medical interventions to prevent and control animal disease on the farm is directly impacting global food security and food safety. Alternatives to antibiotics are needed urgently and the goal of this proposal is to develop a novel replacement for antibiotics.

Poultry production is a suitable paradigm to develop new interventions aimed at all animal production (and potentially along the food chain) as it is the fastest growing sector of animal production globally and common infections caused by gut pathogens such as E. coli, Salmonella, Campylobacter and C.perfingens have extremely high incidence (c.70%) and are associated with a very high prevalence of resistance.  Furthermore, these specific bacteria can be passed from animals to humans.

The vision is that Folium in the first instance, to create Biome Modulators that significantly reduce  pathogens of poultry, Campylobacter, C.perfingens, Salmonella and Avian Pathogenic E. coli, which; 

1.  cause a 5-15% loss of production in the broiler chicken meat industry despite current biosecurity and vaccine treatment

2.  Increase risk of zoonotic disease from bird to human

3.  Inhibit growth and yield of protein from the feed input.

Describe other business assistance that you are seeking from Nutreco

We are looking for support in the development of these products and to partner with FOLIUM to assist in reducing the risk in taking these products and others across other livestock rearing such as aquaculture, swine, dairy and cattle.

Are you available to participate in the final event in the Netherlands 28, 29, and 30 May? All expenses will be covered by Nutreco

Yes

Describe how the prize - a validation trial in our facilities - could boost the development of your business

A valid trial within your business would assist us in validating the in chicken studies which we have planned, and ensure that we prepare the correct data for a Dossier for regulatory purposes in the territories we wish to commericalise.

If you already have a website for your business, please share the URL

teresa debesa 1 month ago

The idea has been progressed to the next milestone.

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Gavin Boerboom 1 month ago

Dear Edward,

Thank you for your submission. You mention in your final paragraph that chicken studies are planned at the moment. May I ask what you are going to measure in those studies. And could you elaborate a bit more on what tests/trials have been done thus far with your solution?

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Edward Fuchs 1 month ago

We can control at species and strain level in a mixed population. Experiments have shown between Log4 and Log6 reductions within 30mins. In the first instance we want to repeat the reduction and time studies.

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CHRISTIAN DELANNOY 1 month ago

Hello Edward. Very interesting submission. I am very curious with regards to the technology you want to you. Could you say what Biome modulators are based on? Also could you provide a reference to the patent mentioned?

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Edward Fuchs 1 month ago

WO2016/177682 & US20160333348 – US Granted 11/07/17

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David Peggs 1 month ago

Hi Edward,
I concur with my colleagues that this is a very interesting area, so thanks for the submission.
I am also very keen to know what the product contains and what type of mechanisms are involved with regards to the gut microbe modulation? Also, have you observed any other health benefits of the product either directly or as a consequence of the microbiota modulation?
Best,
David

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Edward Fuchs 1 month ago

see above, health benefits are anticipated but need long term studies to understand fully

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Saravanan Subramanian 3 weeks ago

Hi Edward,

If I understand correct from you patent, you are using genetic engineering to selectively enhance the endogenous Cas9 system of specific microbe to modulate microbiome towards a selective symbiosis. You have documented this in vitro system using the engineered microbe to inhibit the growth of pathogenic microbes. The product you are offering is a engineered probiotic bacteria, and you wanted to test your product in animal experiments. You mentioned that your product can be delivered through water and encapsulated in the feed system, and one of your target market is aquaculture.
As you may know freshwater fish do not actively drink, and most of fish feed are extruded at high temperature. I am thinking how your product can be administered to fish. Is your product heat-resistant after encapsulation? and what temperature it can tolerate?
Will your product be classified as GMO? Are there any regulatory limitation for commercialization?

Best regards,
Saravanan

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Edward Fuchs 3 weeks ago

We have discussed these types of product concepts with co-developers previously and both the product survival through heat processing and route through regulatory has been considered.

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teresa debesa 2 weeks ago

The idea has been progressed to the next milestone.

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teresa debesa 2 weeks ago

Status label added: Full business case submitted

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