Nutreco Feed Tech Challenge 2018

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SHIITAFORTE new kind of natural inmunostimulators as possible subtitutes of grow-promoters

The idea of the project is to substitute the use of antibiotics as growth promoters in animals with supplements of β-glucan extracts from Shiitake. This kind of extract conforms to the future European Legislation that restricts the use of antibiotics in animals and will promote competitiveness in the livestock sector in the next ten years. This project aims to explore the use of β-glucan extracts in a preventative way in the diet of animals in their immunodepression curves (births phase, weaning phase, etc...) as possible natural immunopotentiators of the animal’s defenses, which would reduce the rate of infections in farms, and will reduce the use of antibiotics as corrective actions in farms.


Reasons why this project could be carried out


Market viability. The development of extracts (dehydrated and liquids) from Shiitake, rich in high molecular weight (1,3 → 1,6) -β-glucans branched (substances with a marked immunomodulatory character), would establish a new type of natural extract for feed that may eventually replace—if not totally, at least partially—the addition of antibiotics to feed, which is currently being done in the livestock sector, adjusting to the increasingly restrictive demands by EU Legislation on the use of antibiotics as growth-promoters. This could all be interesting as a preventive measure in the control of animal diseases in the intestinal tract, and in generating an adequate immune response to diseases of bacterial and viral origin.


Technical viability. Shiitake mushroom (Lentinula edodes) is an edible mushroom native to China, which has been cultivated for more than 1,000 years throughout Asia. Traditionally, in its country of origin, this mushroom was grown for domestic use in the trunks of a tree. Shiitake is a mushroom that has been used in traditional Chinese cuisine for thousands of years, even prescribed as a remedy for physical exhaustion, forming part of traditional Asian dishes. Shiitake is a healthy and natural food, it is not a GMO (genetically modified organism) and there are no GMOs involved in its fruiting process. Nutritionally it has a superior protein quality, possessing 41% of essential amino acids of its protein fraction (24%) and a non-negligible percentage of dietary fiber (30%). Of these fibers a very high percentage have a high molecular weight, branched 1,3 → 1,6 β-glucans, which gives to the extract unrivaled immunostimulatory properties, being also a very important non-animal source of vitamin D and mineral salts involved in bone growth.


According to extensive existing scientific literature, an increase of immunomodulatory parameters has been clearly verified and a protective effect against viral and bacterial infections has been proven following the implementation of this type of extract in the feeding of many livestock species— monogastrics and ruminants, including rabbits, swine, sheep and cows—in meat and milk production, even in fish farms. The proposed administration would be carried out by adding extracts either to the feed (dehydrated extract) or to the water (liquid extracts), so that indirectly a supplemented feed could be generated, indicated for periods of immunosuppression of the animal or a product indicated for adding to the drinking water.


Its effect on the immune system is being studied in depth, in different species with promising results in terms of reducing inflammation, and as an activator of the immune system. That is why, the next logical step is to be able to evaluate the immunostimulatory capacity of this type of product against tangible infections existing in the current livestock.


Economic viability. La Rioja (Spain), which is one of the main areas in all of Europe—3% of worldwide production—for the production of edible mushrooms produced indoors, has been intensively cultivating Shiitake for ten years. This has been possible thanks to experience in the sector dating from the 1970s, the edible-mushroom companies structure and the proximity to existing composting plants in the area due to the cultivation of other types of indoor mushrooms. That is one of the reasons that why this project will grow immediately, because all the raw material needed for the transformation factory are near the facilities and this will reduce the transportation costs considerably.

Describe the problem your company wishes to solve and how your product or service will solve it

The development of this kind extracts from Shiitake would establish a new type of natural extract for feed that may eventually replacethe addition of antibiotics to feed, which is currently being done in the livestock sector, adjusting to the increasingly restrictive demands by EU Legislation on the use of antibiotics as growth-promoters.

Describe other business assistance that you are seeking from Nutreco

Commercial support in the sale and distribution of this new type of products along the EU in differents livestock sectors (cattle, pigs, sheep, and goats).

 

Are you available to participate in the final event in the Netherlands 28, 29, and 30 May? All expenses will be covered by Nutreco

Yes

Describe how the prize - a validation trial in our facilities - could boost the development of your business

This prize would give to know this new kind of products in diferent livestocks sectors trough the NUTRECO comercial distribution along UE.

If you already have a website for your business, please share the URL

GLUCANFEED don´t have website yet.

edited on Mar 8, 2018 by Hugo Guillén Fuerte

teresa debesa 4 months ago

The idea has been progressed to the next milestone.

Reply 0

David Peggs 4 months ago

Hi Hugo, thanks for your submission.

Can you elaborate a little bit more about what type of parameters you would like to analyse to evaluate the immunostimulatory capacity of your product/products?
Also, you are focusing the product on terrestrial animals, but do you think there is potential for your products to be used in aquaculture now or in the future?

Best,
David

Reply 1

Hugo Guillén Fuerte 4 months ago

Hello David, I answer each of the questions you have asked me:

Can you elaborate a little bit more about what type of parameters you would like to analyse to evaluate the immunostimulatory capacity of your product/products?

We would like to evaluate parameters of livestock exploitation, in milk cattle and pigs, in two target populations:

-In mothers before, during, and after the lactation period, we would like to evaluate the percentage of morbidity and mortality, the birth rate, the abortion rate, the insemination/failure rate, the conversion rate (CR), and the average daily gain (ADP). In addition, we would like to evaluate the milk´s quantity (liters of milk / day) and quality provided by the mothers (composition of the milk, somatic cell count, fatty acid content, pH) whether if it increases or decreases the quantity and quality of milk, when the nursing mothers have a better immune system. In addition, we would like to evaluate too, the number of days it takes to recover the animal after suffering an infectious outbreak by counting liters of milk/day, or ADP.

-In newborn animals after being weaned (where they suffer a noticeable lowering of the immune system) we would like to evaluate the mortality and morbidity rate, the conversion index (CI), and average daily gain (ADP). Also, we would be interested to evaluate the number of days, that the animal takes to recover after suffering an infectious outbreak (to recover a standard ADP).

Do you think there is potential for your products to be used in aquaculture now or in the future?

All the studies that GLUCANFEED had made previously has been realized in mammals species, and the aplications with β-glucans in non-mammals species should not be extrapolated in the same terms. But the bibliographic references about this hipothesis are clearly positive. Since 20 years ago, there are been realized many studies, that study the relationship between β-glucans from many sources (Sacharomyces cerevisiae, Laminaria hyperborea, Poria cocos, etc...) with many aquaculture species (Oreochromis niloticus, Cyprinus carpio, Salmo salar, etc...), but there are not published recent studies about the relationship between lentinan and aquaculture species.

I think that lentinan, the active component present in our products, can be used as a grow promoter of in feeds for aquaculture as a preventive measure against infections, not only at fattening phase (improvement of ADP, CR, etc. ..) but also the reproduction phase, where it would improve the conditions of reproduction of the species (increase in the number of roes, etc ...). Its application should be added in solid format in feeds composition before the palletization process.

Reply 0

Adriano Perez Bonilla 4 months ago

Dear Hugo, thanks for your submission in the Nutreco Feed Tech Challenge 2018.
I would like to ask some questions:

1) What do you think are the unique points of differentation of your Shiitaforte comparing current raw matherials which have also a inmune response in monogastrics (i.e: Spray dried porcine/bovine; Egg poder...etc)?

2) What is the forecast of the mushroom production in order to have an estable manufacturing production?. You mentioned La Rioja & Asia, but i wonder if this Shiitaforte would be delivered around the globe, what could be the strategic plan?

Thanks again for your contribution.
Kind Regards
Adriano

Reply 0

Hugo Guillén Fuerte 3 months ago

1) What do you think are the unique points of differentation of your Shiitaforte comparing current raw matherials which have also a inmune response in monogastrics (i.e: Spray dried porcine/bovine; Egg poder...etc)?

Not all β-glucans have an immunomodulatory effect. If you look in the bibliographical references, it is observed that only the fungal matrices that possess 1,3,6 branched beta-glucans (lentinan) have an immunomodulatory effect on mammalian animals.

References in different species

Soluble (1 → 3) β-D-glucan purified from Candida albicans. Biologic effects and distribution in blood and organs in rabbits. Yoshida et al. Lab. Clin. Med.1996

Effect of dietary supplementation of β-1,3-1,6-glucan on reproductive performance and immunity of New Zealand White does and their pups. H H. Wu et al. Livestock Science 135 (2011) 70-75 71

(1 → 3) -particular linear β-glucan and other formulations based on β-glucan its effect on cattle and birds. M. Pedroso et al. Rev. Salud Anim. 34 2 (2012) 70-77

REVIEW Immunostimulants in Teleostos Probiotics, β-glucans, and LPS. M.A.Vásquez et al. Orinoquia 16 1 (2012)

Dietary β-1,3 glucan potentiates innate immunity and disease resistance of Clarias batrachus. J. Kumari et al. Journal of Fish Diseases 2006, 29, 95-101

Effects of β-glucan on the growth, immune responses and resistance of Apostichopus japonicus against Vibrio splendidus infection. Y. Zhao et al. Aquaculture 315 (2011) 269-274

Effect of dietary β-glucan on growth performance, fecal microbial shedding and immunological responses after lipopolysaccharide challenge in weaned pigs. T.X. Zhou et al. Animal Feed Science and Technology 179 (2013) 85-92

Dietary (1,3_1,6) -β-D-glucan decreases tumor growth factor β expression in the lung of the neonatal piglet. Thorum SC, et al. Nutr Res (2013)

2) What is the forecast of the mushroom production in order to have an estable manufacturing production?. You mentioned La Rioja & Asia, but i wonder if this Shiitaforte would be delivered around the globe, what could be the strategic plan?

There are production of Shiitake in other countries such as Eastern Europe, USA, Israel, South America, especially Argentina and Chile and other countries such as Mexico. Therefore, the shiitake's production is consolidating all over the world, the price of the raw material has been stable in recent years and it is expected that it may fall when new producers are added, so we deduce that there are no shortage problems in the medium term of raw material in obtaining the final product.


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Saravanan Subramanian 3 months ago

Hi Hugo,

Indeed, very interesting idea. As I understood from your post you are aiming to extract branched 1,3 → 1,6 β-glucans from Shiitake mushroom. You have product in dry (dehydrated extract) and liquid (liquid extracts) form.

What is active concentration of β-glucans present in your product Glucanfeed? Does the concentration & shelf-life of β-glucan differs between dehydrated extract and liquid extract?
How your product is functionally and economically different from β-glucan products extracted from brewers yeast, Sacharomyces cerevisiae?

Best regards,
Saravanan

Reply 0

teresa debesa 3 months ago

The idea has been progressed to the next milestone.

Reply 0

teresa debesa 3 months ago

Status label added: Full business case submitted

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